Latex Allergens


[ English | Japanese ]

Latex allergens that have already been registered by WHO-IUIS can be tabulated with their predicted physiological roles as follows.

Table. Registered Natural Rubber-Latex Allergens
Name Trivial name Predicted physiological roles Accession number (Protein) References
Hev b 1 rubber elongation factor rubber biosynthesis P15252 1
Hev b 2 beta-1,3-glucanases defense-related protein Q7XJ83, P52407 2
Hev b 3 small rubber-particle protein rubber biosynthesis O82803 3
Hev b 4 microhelix component defense-related protein Q8WPJ2 4
Hev b 5 acidic latex protein - Q39967 5
Hev b 6.01
Hev b 6.02
Hev b 6.03
prohevein, hevein preprotein
hevein
prohevein C-terminal fragment
defense-related protein
(latex coagulation)
O49860, P02877, P80359 6
Hev b 7.01 = Hev b 13 (renamed)
Hev b 7.02
patatin homologue from B-serum
patatin homologue from C-serum
defense-related protein
inhibitor of rubber biosynthesis
O04008, O81984, O65811,
Q9SEM0
7
Hev b 8 latex profilin structural protein O65812, Q9STB6, Q9M7N0,
Q9M7M9, Q9M7M8, Q9LEI8
8
Hev b 9 latex enolase glycolytic enzyme Q9LEJ0, Q9LEI9 9
Hev b 10 Mn-superoxide dismutase destruction of radicals P35017, Q9STB5, Q9FSJ2 10
Hev b 11 class I endochitinase defense-related protein Q949H3, Q8GUD7 11
Hev b 12 lipid transfer protein defense-related protein Q8RYA8 12
Hev b 13 (= Hev b 7.01) latex esterase
Early Nodule Specific Protein (ENSP)
defense-related protein Q7Y1X1 13


Important Links - Informative Resources on Allergenic Proteins
Official List of Allergens and Allergen Nomenclature (WHO-IUIS Allergen Nomenclature Subcommittee)
The Allergen Database (The Central Science Laboratory)
The Allergen Sequence Database (National Center for Food Safety and Technology)
Structural Database of Allergenic Proteins (The University of Texas Medical Branch, SDAP) good!
SWISS-PROT Allergen Index
Sequence Comparison to Allergenic Proteins (Allermatch)
Food Allergy Research and Resource Program (Farrp)
Food Allergens of Plant Origin (Protall)
A Database of Allergenic Molecules (Allergome) good!

Web Sites Especially Related to Latex Allergens
Guthrie Research Institute (LEAP test, ASTM tests)
FIT Biotech (FITkit)
BIOMAY Wien/Vienna (Recombinant allergens for research use)
PlasmaLab International (Human plasma for research use)
VBC-Genomics (Immuno solid-phase allergen chip)


References

[0] Recent reviews, Yeang, H.Y.: Natural rubber latex allergens: new developments., Curr. Opin. Allergy Clin. Immunol., 4, 99-104 (2004); Wagner, S. and Breiteneder, H.: Hevea brasiliensis latex allergens: current panel and clinical relevance., Int. Arch. Allergy Immunol., 136, 90-97 (2005).

[1] Czuppon, A.B., Chen, Z., Rennert, S., Engelke, T., Meyer, H.E., Heber, M. and Baur, X.: The rubber elongation factor of rubber trees (Hevea brasiliensis) is the major allergen in latex., J. Allergy Clin. Immunol., 92, 690-697 (1993); Yeang, H.Y., Cheong, K.F., Sunderasan, E., Hamszah, S., Chew, N.P., Hamid, S., Hamilton, R.G. and Cardosa, M.J.: The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy., J. Allergy Clin. Immunol., 98, 628-639 (1996).

[2] Sunderasan, E., Hamzah, S., Hamid, S., Ward, M.A., Yeang, H.Y. and Cardosa, M.J.: Latex B-serum beta-1,3-glucanase (Hev b II) and a component of the microhelix (Hev b IV) are major latex allergens., J. Nat. Rubb. Res., 10, 82-99 (1995); Alenius, H., Kalkkinen, N., Lukka, M., Reunala, T., Turjanmaa, K., Makinen-Kiljunen, S., Yip, E. and Palosuo, T., Prohevein from the rubber tree (Hevea brasiliensis) is a major latex allergen., Clin. Exp. Allergy, 24, 659-665 (1995).

[3] Yeang, H.Y., Cheong, K.F., Sunderasan, E., Hamszah, S., Chew, N.P., Hamid, S., Hamilton, R.G. and Cardosa, M.J.: The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy., J. Allergy Clin. Immunol., 98, 628-639 (1996); Yeang, H.Y., Ward, M.A., Zamri, A.S.M. Dennis, M.S. and Light, D.R.: Amino acid sequence similarity of Hev b 3 to two previously reported 27- and 23-kDa latex proteins allergenic to spina bifida patients., Allergy, 53, 513-519 (1998); Oh, S.K., Kang, H., Shin, D.H., Yang, J., Chow, K.S., Yeang, H.Y., Wagner, B., Breiteneder, H. and Han, K.H.: Isolation, characterization, and functional analysis of a novel cDNA clone encoding a small rubber particle protein from Hevea brasiliensis., J. Biol. Chem., 274, 17132-17138 (1999); Wagner, B., Krebitz, M., Buck, D., Niggemann, B., Yeang, H.Y., Han, K.-H., Scheiner, O. and Breiteneder, H.: Cloning, expression, and characterization of recombinant Hev b 3, a Hevea brasiliensis protein associated with latex allergy in patients with spina bifida., J. Allergy Clin. Immunol., 104, 1084-1092 (1999).

[4] Sunderasan, E., Hamzah, S., Hamid, S., Ward, M.A., Yeang, H.Y. and Cardosa, M.J.: Latex B-serum beta-1,3-glucanase (Hev b II) and a component of the microhelix (Hev b IV) are major latex allergens., J. Nat. Rubb. Res., 10, 82-99 (1995); Sunderasan, E, Chow, K.-S., Ward, M.A., Yeang, H.-Y.: Hev b 4 heavy peptide identified as latex cyanogenic glucosidase., J. Allergy Clin. Immunol., 109, No.1, S333 (2002); Sunderasan, E., Ward, M.A. and Yeang, H.Y.: Isolation and chracterization of latex cyanogenic glucosidase in Hevea brasiliensis., J. Rubber Res., 5, 244-252 (2002)! .

[5] Akasawa, A., Hsieh, L.-S., Martin, B.M., Liu, T. and Lin, Y.: A novel acidic allergen, Hev b 5, in latex., J. Biol. Chem., 271, 25389-25393 (1996); Slater, J.E., Vedvick, T., Arthur-Smith, A., Trybul, D.E. and Kekwick, R.G.O.: Identification, cloning, and sequence of a major allergen (Hev b 5) from natural rubber latex (Hevea brasiliensis)., J. Biol. Chem., 271, 25394-25399 (1996).

[6] Alenius, H., Kalkkinen, N., Lukka, M., Reunala, T., Turjanmaa, K., Makinen-Kiljunen, S., Yip, E. and Palosuo, T., Prohevein from the rubber tree (Hevea brasiliensis) is a major latex allergen., Clin. Exp. Allergy, 24, 659-665 (1995); Chen, Z., Posch, A., Lohaus, C., Raulf-Heimsoth, M., Meyer, H.E. and Baur, X.: Isolation and identification of hevein as a major IgE-binding polypeptide in Hevea latex., J. Allergy Clin. Immunol., 99, 402-409 (1997); Beezhold, D.H., Kostyal, D.A. and Sussman, G.L.: IgE epitope analysis of the hevein preprotein; a major latex allergen., Clin. Exp. Immunol., 108, 114-121 (1997).

[7] Beezhold, D.H., Sussman, G.L., Kostyal, D.A. and Chang, N.-S.: Identification of a 46-kd latex protein allergen in health care workers., Clin. Exp. Immunol., 98, 408-413 (1994); Kostyal, D.A., Hickey, V.L., Noti, J.D., Sussman, G.L. and Beezhold, D.H.: Cloning and characterization of a latex allergen (Hev b 7): homology to patatin, a plant PLA2., Clin. Exp. Immunol., 112, 355-362 (1998); Sowka, S., Wagner, S., Krebitz, M., Arija-Mad-Arif, S., Yusof, F., Kinaciyan, T., Brehler, R., Scheiner, O. and Breiteneder, H.: cDNA cloning of the 43-kD latex allergen Hev b 7 with sequence similarity to patatins and its expression in the yeast Pichia pastoris., Eur. J. Biochem., 255, 213-219 (1998); Yeang, H.Y., Chow, K.S., Yusof, F., Arif, S.A., Chew, N.P. and Loke, Y.H.: Appraisal of latex glove proteins in the induction of sensitivity to multiple latex allergens., J. Investig. Allergol. Clin. Immunol., 10, 215-222 (2000).

[8] Vallier, P., Balland, S., Harf, R., Valenta, R. and Deviller, P.: Identification of profilin as an IgE-binding component in latex from Hevea brasiliensis: clinical implications., Clin. Exp. Allergy, 25, 332-339 (1995); Nieto, A., Mazon, A., Estornell, F., Boquete, M., Carballada, F., Martinez, A., Asturias, J.A., Aguirre, M., Martinez, J. and Palacios, R.: Profilin, a relevant allergen in latex allergy., J. Allergy Clin. Immunol., 101, S207 (1998); Rihs, H.P., Chen, Z., Rozynek, P., Baur, X., Lundberg, M. and Cremer, R.: PCR-based cloning, isolation, and IgE-binding properties of recombinant latex profilin (rHev b 8)., Allergy, 55, 712-717 (2000).

[9] Wagner, S., Breiteneder, H., Simon-Nobbe, B., Susani, M., Krebitz, M., Niggemann, B., Brehler, R., Scheiner, O. and Hoffmann-Sommergruber, K.: Hev b 9, an enolase and a new cross-reactive allergen from hevea latex and molds. Purification, characterization, cloning and expression., Eur. J. Biochem., 267, 7006-7014 (2000).

[10] Wagner, S., Sowka, S., Mayer, C., Crameri, R., Focke, M., Kurup, V.P., Scheiner, O. and Breiteneder, H.: Identification of a Hevea brasiliensis latex manganese superoxide dismutase (Hev b 10) as a cross-reactive allergen., Int. Arch. Allergy Immunol., 125, 120-127 (2001).

[11] O'Riordain, G., Radauer, C., Hoffmann-Sommergruber, K., Adhami, F., Peterbauer, C.K., Blanco, C., Godnic-Cvar, J., Scheiner, O., Ebner, C. and Breiteneder, H.: Cloning and molecular characterization of the Hevea brasiliensis allergen Hev b 11, a class I chitinase., Clin. Exp. Allergy, 32, 455-462 (2002); Rihs, H.P., Dumont, B., Rozynek, P., Lundberg, M., Cremer, R., Bruning, T. and Raulf-Heimsoth, M.: Molecular cloning, purification, and IgE-binding of a recombinant class I chitinase from Hevea brasiliensis leaves (rHev b 11.0102)., Clin. Exp. Allergy, 58, 246-251 (2003).

[12] Beezhold, D.H., Hickey, V.L., Kostyal, D.A., Puhl, H., Zuidmeer, L., van Ree, R. and Sussman, G.L.: Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex protein., Ann Allergy Asthma Immunol, 90, 439-445 (2003).

[13] Bernstein, D,I,, Biagini, R.E., Karnani, R., Hamilton, R., Murphy, K., Bernstein, C., Arif, S.A., Berendts, B. and Yeang, H.Y.: In vivo sensitization to purified Hevea brasiliensis proteins in health care workers sensitized to natural rubber latex., J. Allergy Clin. Immunol., 111, 610-616 (2003); Arif, S.A., Hamilton, R.G., Yusof, F., Chew, N.P., Loke, Y.H., Nimkar, S., Beintema, J.J. and Yeang, H,Y.: Isolation and characterization of the early nodule specific protein homologue (Hev b 13), an allergenic lipolytic esterase from Hevea brasiliensis latex., J. Biol. Chem., 279, 23933-23941 (2004).



More about Latex Allergy


Go to the home page of DMD

NIHS / DMD / yagami@nihs.go.jp